Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic - download pdf or read online

By Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. Wendisch (eds.)

ISBN-10: 3540485953

ISBN-13: 9783540485957

ISBN-10: 3540485961

ISBN-13: 9783540485964

Amino Acids Biosynthesis offers the present wisdom of basic in addition to utilized microbiology of amino acids. subject matters mentioned are the amino acid biosynthetic pathways, their genetic and biochemical law, shipping of amino acids and genomics of manufacturing microorganisms. The characterization of the keep watch over mechanisms of amino acid biosynthesis has printed insights into ideas of genetic and biochemical rules, similar to transcriptional regulators and a brand new type of regulatory parts, the riboswitch.

The quantity additional offers with the metabolic engineering of microorganisms for the biotechnological construction of amino acids to be used as prescription drugs and, really, as foodstuff and feed ingredients. entire experiences are given of contemporary achievements to let or enhance construction of amino acids and dipeptides by means of fermentation and enzyme catalysis. the following, the actual concentration is on metabolic engineering, the rational development of metabolic features utilizing recombinant DNA technology.

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Extra resources for Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering

Sample text

Metab Eng 4:282–290 Clement Y, Escoffier B, Trombe MA, Lanéele G (1984) Is glutamate excreted by its uptake system in Corynebacterium glutamicum? A working hypothesis. J Gen Microbiol 130:2589–2594 Clément Y, Lanéele G (1986) Glutamate excretion mechanism in Corynebacterium glutamicum: triggering by biotin starvetion or by surfactant addition. J Gen Microbiol 132:925–929 Collins MD, Goodfellow M, Minnikin DE (1982) A survey of the structure of mycolic acids in Corynebacterium and related taxa. J Gen Microbiol 128:129–149 Csonka LN (1981) Proline over-production results in enhanced osmotolerance in Salomonella typhimurium.

As an important milestone, the glutamate producing soil bacterium Corynebacterium glutamicum was isolated in 1956 and soon received interest to be used for production of another amino acid stemming from the TCA cycle: lysine. Within a few years the first lysine producing strains were obtained. The past 50 years following the discovery of C. glutamicum were characterized by a huge progress towards understanding the physiology of this organism and developing and optimizing industrial production strains.

A common feature involved in the different pathways concerns the regulation of pathway flux by feedback inhibition of aspartate kinase. In C. glutamicum only one isoenzyme of aspartate kinase (or aspartokinase) exists, which is encoded by two genes, lysCα and lysCβ, representing the coding sequences for the two subunits of the enzyme (Kalinowski et al. 1990). Its activity is bio- 42 C. Wittmann · J. Becker Fig. 2 The four pathways of d,l-diaminopimelate and lysine synthesis from aspartate in prokaryotes: succinylase pathway (A); acetylase pathway (B), dehydrogenase pathway (C), and aminotransferase pathway (D).

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Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering by Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. Wendisch (eds.)


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